Resins for Solid Phase Peptide Synthesis: Application Guide

Resins for Fmoc SPPS

Products

Resins

Attachment

Cleavage

Peptide Acid

Wang Resin

DIC/HOBt/DMAP

95%TFA/Scavenger

4-Benzyloxybenzyl bromide Resin

Cesium salt or KF

95% TFA/Scavenger

Protected Peptide Acid

2-Chlorotrityl Chloridde Resin

DIPEA

EtOH/TFE/DCM(1:2:7) 1%TFE in DCM

HMBA-MBHA Resin

DIC/HOBt/DMAP

60%TFA in DCM

Peptide Amide

Rink Amide Resin

HOBt/HBTU/DIPEA

95%TFA/Scavenger

Rink Amide-MBHA Resin

HOBt/HBTU/DIPEA

95%TFA/Scavenger

Rink Amide-AM Resin

HOBt/HBTU/DIPEA

95%TFA/Scavenger

HMBA-MBHA Resin

DIC/HOBt/DMAP

Amine

Protected Peptide Amide

Sieber Resin

HOBt/HBTU/DIPEA

1% TFA in DCM

Peptide Ester

HMBA-MBHA Resin

DIC/HOBt/DMAP

ROH/DIEA/DMF

Peptide Hydrazide

HMBA-MBHA Resin

DIC/HOBt/DMAP

Hydrazine/DMF

Hydrazine-2-Chlorotrityl Resin

DIC/HOBt

1% to 5% TFA in DCM

Resins for Boc SPPS

Products

Resins

Attachment

Cleavage

Peptide Acid

Merrifield Resin

Cesium salt or KF

HF or TFMSA

Hydroxymethyl Resin

DIC/HOBt/DMAP

HFor TFMSA

PAM Resin

DIC/HOBt/DMAP

HFor TFMSA

Protected Peptide Acid

Oxime Resin

DIC/HOBt/DMAP

NaOH/Dioxane

Peptide Amide

MBHA Resin

DIC/HOBt

HF or TFMSA

BHA Resin

DIC/HOBt

HF

Peptide Hydrazide

Oxime Resin

DIC/HOBt/DMAP

Hydrazine/ DMF

Peptide Ester

Oxime Resin

DIC/HOBt/DMAP

MeOH/DMF/TEA

Bead Size Conversion Table

 

Mesh

µm

Mesh

µm

Mesh

µm

 

20

850

60

250

200

75

 

25

710

70

212

325

45

 

35

500

100

150

400

38

 

50

300

140

106

  
Close Bitnami banner
Bitnami